Patterns of expression of DNA repair genes and relapse from melanoma.

ABSTRACT:

Purpose

To use gene expression profiling of formalin-fixed primary melanoma samples to detect expression patterns that are predictive of relapse and response to chemotherapy.

Experimental design

Gene expression profiles were identified in samples from two studies (472 tumors). Gene expression data for 502 cancer-related genes from these studies were combined for analysis.

Results

Increased expression of DNA repair genes most strongly predicted relapse and was associated with thicker tumors. Increased expression of RAD51 was the most predictive of relapse-free survival in unadjusted analysis (hazard ratio, 2.98; P = 8.80 × 10(-6)). RAD52 (hazard ratio, 4.73; P = 0.0004) and TOP2A (hazard ratio, 3.06; P = 0.009) were independent predictors of relapse-free survival in mu

SUBMITTER: Jewell R 

PROVIDER: S-EPMC2972254 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature