Single-cell and coupled GRN models of cell patterning in the Arabidopsis thaliana root stem cell niche.

ABSTRACT:

Background

Recent experimental work has uncovered some of the genetic components required to maintain the Arabidopsis thaliana root stem cell niche (SCN) and its structure. Two main pathways are involved. One pathway depends on the genes SHORTROOT and SCARECROW and the other depends on the PLETHORA genes, which have been proposed to constitute the auxin readouts. Recent evidence suggests that a regulatory circuit, composed of WOX5 and CLE40, also contributes to the SCN maintenance. Yet, we still do not understand how the niche is dynamically maintained and patterned or if the uncovered molecular components are sufficient to recover the observed gene expression configurations that characterize the cell types within the root SCN. Mathematical and computational tools have proven usefu

SUBMITTER: Azpeitia E 

PROVIDER: S-EPMC2972269 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature