Mitochondrial protection attenuates inflammation-induced impairment of neurogenesis in vitro and in vivo.

ABSTRACT: The impairment of hippocampal neurogenesis has been linked to the pathogenesis of neurological disorders from chronic neurodegenerative disease to the progressive cognitive impairment of children who receive brain irradiation. Numerous studies provide evidence that inflammation downregulates neurogenesis, with multiple factors contributing to this impairment. Although mitochondria are one of the primary targets of inflammatory injury, the role of mitochondrial function in the modulation of neurogenesis remains relatively unstudied. In this study, we used neurosphere-derived cells to show that immature doublecortin (Dcx)-positive neurons are uniquely sensitive to mitochondrial inhibition, demonstrating rapid loss of mitochondrial potential and cell viability compared with glial cells and mo

SUBMITTER: Voloboueva LA 

PROVIDER: S-EPMC2972310 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature