Genome-wide association for smoking cessation success in a trial of precessation nicotine replacement.

ABSTRACT: Abilities to successfully quit smoking display substantial evidence for heritability in classic and molecular genetic studies. Genome-wide association (GWA) studies have demonstrated single-nucleotide polymorphisms (SNPs) and haplotypes that distinguish successful quitters from individuals who were unable to quit smoking in clinical trial participants and in community samples. Many of the subjects in these clinical trial samples were aided by nicotine replacement therapy (NRT). We now report novel GWA results from participants in a clinical trial that sought dose/response relationships for "precessation" NRT. In this trial, 369 European-American smokers were randomized to 21 or 42 mg NRT, initiated 2 wks before target quit dates. Ten-week continuous smoking abstinence was assessed on the b

SUBMITTER: Uhl GR 

PROVIDER: S-EPMC2972392 | biostudies-literature | 2010 Nov-Dec

REPOSITORIES: biostudies-literature