Localization and androgen regulation of metastasis-associated protein 1 in mouse epididymis.

ABSTRACT:

Background

Metastasis-associated protein 1 (MTA1), the founding member of the MTA family of genes, can modulate transcription by influencing the status of chromatin remodeling. Despite its strong correlation with the metastatic potential of cancer cells, MTA1 can also regulate crucial cellular pathways by modifying the acetylation status. We have previously reported the presence of MTA1/MTA1 in human and mouse testes, providing the evidence for its involvement in the regulation of testicular function during murine spermatogenesis. The objective of present study was to further assess the localization of MTA1 in mouse epididymis on both transcriptional and translational level, and then to explore whether MTA1 expression is regulated by androgens and postnatal epididymal development.<

SUBMITTER: Ma L 

PROVIDER: S-EPMC2972736 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature