Shunting inhibition controls the gain modulation mediated by asynchronous neurotransmitter release in early development.

ABSTRACT: The sensitivity of a neuron to its input can be modulated in several ways. Changes in the slope of the neuronal input-output curve depend on factors such as shunting inhibition, background noise, frequency-dependent synaptic excitation, and balanced excitation and inhibition. However, in early development GABAergic interneurons are excitatory and other mechanisms such as asynchronous transmitter release might contribute to regulating neuronal sensitivity. We modeled both phasic and asynchronous synaptic transmission in early development to study the impact of activity-dependent noise and short-term plasticity on the synaptic gain. Asynchronous release decreased or increased the gain depending on the membrane conductance. In the high shunt regime, excitatory input due to asynchronous releas

SUBMITTER: Volman V 

PROVIDER: S-EPMC2973817 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature