Variance heterogeneity analysis for detection of potentially interacting genetic loci: method and its limitations.

ABSTRACT:

Background

Presence of interaction between a genotype and certain factor in determination of a trait's value, it is expected that the trait's variance is increased in the group of subjects having this genotype. Thus, test of heterogeneity of variances can be used as a test to screen for potentially interacting single-nucleotide polymorphisms (SNPs). In this work, we evaluated statistical properties of variance heterogeneity analysis in respect to the detection of potentially interacting SNPs in a case when an interaction variable is unknown.

Results

Through simulations, we investigated type I error for Bartlett's test, Bartlett's test with prior rank transformation of a trait to normality, and Levene's test for different genetic models. Additionally, we derived an analytical

SUBMITTER: Struchalin MV 

PROVIDER: S-EPMC2973850 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature