Hierarchical order of coexisting pre- and postsynaptic forms of long-term potentiation at synapses in amygdala.

ABSTRACT: Synaptic rules that may determine the interaction between coexisting forms of long-term potentiation (LTP) at glutamatergic central synapses remain unknown. Here, we show that two mechanistically distinct forms of LTP could be induced in thalamic input to the lateral nucleus of the amygdala (LA) with an identical presynaptic stimulation protocol, depending on the level of postsynaptic membrane polarization. One form of LTP, resulting from pairing of postsynaptic depolarization and low-frequency presynaptic stimulation, was both induced and expressed postsynaptically ("post-LTP"). The same stimulation in the absence of postsynaptic depolarization led to LTP, which was induced and expressed presynaptically ("pre-LTP"). The inducibility of coexisting pre- and postsynaptic forms of LTP at syna

SUBMITTER: Shin RM 

PROVIDER: S-EPMC2973868 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature