POLD2 and KSP37 (FGFBP2) correlate strongly with histology, stage and outcome in ovarian carcinomas.

ABSTRACT:

Background

Epithelial ovarian cancer (EOC) constitutes more than 90% of ovarian cancers and is associated with high mortality. EOC comprises a heterogeneous group of tumours, and the causes and molecular pathology are essentially unknown. Improved insight into the molecular characteristics of the different subgroups of EOC is urgently needed, and should eventually lead to earlier diagnosis as well as more individualized and effective treatments. Previously, we reported a limited number of mRNAs strongly upregulated in human osteosarcomas and other malignancies, and six were selected to be tested for a possible association with three subgroups of ovarian carcinomas and clinical parameters.

Methodology/principal findings

The six selected mRNAs were quantified by RT-qPCR in bio

SUBMITTER: Elgaaen BV 

PROVIDER: S-EPMC2973954 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature