Synthesis of amino acid derived enaminones via Wolff rearrangement using vinylogous amides as carbon nucleophiles.

ABSTRACT: Cyclic enaminones were synthesized in high yields from amino acids in two steps via Wolff rearrangement. The cyclization represents a rare 6-exo-dig cyclization involving a ketene as an electrophile. No racemization was observed during this reaction.

SUBMITTER: Seki H 

PROVIDER: S-EPMC2974010 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature