Efficacy of esomeprazole for treatment of poorly controlled asthma.

ABSTRACT:

Background

Gastroesophageal reflux is common among patients with asthma but often causes mild or no symptoms. It is not known whether treatment of gastroesophageal reflux with proton-pump inhibitors in patients who have poorly controlled asthma without symptoms of gastroesophageal reflux can substantially improve asthma control.

Methods

In a parallel-group, double-blind trial, we randomly assigned 412 participants with inadequately controlled asthma, despite treatment with inhaled corticosteroids, and with minimal or no symptoms of gastroesophageal reflux to receive either 40 mg of esomeprazole twice a day or matching placebo. Participants were followed for 24 weeks with the use of daily asthma diaries, spirometry performed once every 4 weeks, and questionnaires that asked a

SUBMITTER: American Lung Association Asthma Clinical Research Centers 

PROVIDER: S-EPMC2974569 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature