Evolution and functional divergence of the anoctamin family of membrane proteins.

ABSTRACT:

Background

The anoctamin family of transmembrane proteins are found in all eukaryotes and consists of 10 members in vertebrates. Ano1 and ano2 were observed to have Ca2+ activated Cl- channel activity. Recent findings however have revealed that ano6, and ano7 can also produce chloride currents, although with different properties. In contrast, ano9 and ano10 suppress baseline Cl- conductance when co-expressed with ano1 thus suggesting that different anoctamins can interfere with each other. In order to elucidate intrinsic functional diversity, and underlying evolutionary mechanism among anoctamins, we performed comprehensive bioinformatics analysis of anoctamin gene family.

Results

Our results show that anoctamin protein paralogs evolved from several gene duplication events f

SUBMITTER: Milenkovic VM 

PROVIDER: S-EPMC2974728 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature