Discover protein complexes in protein-protein interaction networks using parametric local modularity.

ABSTRACT:

Background

Recent advances in proteomic technologies have enabled us to create detailed protein-protein interaction maps in multiple species and in both normal and diseased cells. As the size of the interaction dataset increases, powerful computational methods are required in order to effectively distil network models from large-scale interactome data.

Results

We present an algorithm, miPALM (Module Inference by Parametric Local Modularity), to infer protein complexes in a protein-protein interaction network. The algorithm uses a novel graph theoretic measure, parametric local modularity, to identify highly connected sub-networks as candidate protein complexes. Using gold standard sets of protein complexes and protein function and localization annotations, we show our algori

SUBMITTER: Kim J 

PROVIDER: S-EPMC2974752 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature