Synthesis and biological evaluation of (+/-)-dinemasone C and analogues.

ABSTRACT: Dinemasone C was prepared in three steps (8% overall yield) from cis-tetrahydro-4-hydroxy-6-methyl-2-pyrone by aldol reaction with 2,4-hexadienal, epoxidation followed by cyclization, and epimerization of the ring fusion. Dinemasone C, epi-dinemasone C, anhydrodinemasone BC, and nor-dinemasone B are active against bacteria, including Legionella pneumophila Corby, algae, and fungi.

SUBMITTER: Stewart AM 

PROVIDER: S-EPMC2975019 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature