Nucleosome structure incorporated histone acetylation site prediction in Arabidopsis thaliana.

ABSTRACT:

Background

Acetylation is a crucial post-translational modification for histones, and plays a key role in gene expression regulation. Due to limited data and lack of a clear acetylation consensus sequence, a few researches have focused on prediction of lysine acetylation sites. Several systematic prediction studies have been conducted for human and yeast, but less for Arabidopsis thaliana.

Results

Concerning the insufficient observation on acetylation site, we analyzed contributions of the peptide-alignment-based distance definition and 3D structure factors in acetylation prediction. We found that traditional structure contributes little to acetylation site prediction. Identified acetylation sites of histones in Arabidopsis thaliana are conserved and cross predictable with t

SUBMITTER: Zhao C 

PROVIDER: S-EPMC2975415 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature