The multicenter uveitis steroid treatment trial: rationale, design, and baseline characteristics.

ABSTRACT:

Purpose

To describe the design and methods of the Multicenter Uveitis Steroid Treatment (MUST) trial and the baseline characteristics of enrolled patients.

Design

Baseline data from a 1:1 randomized, parallel treatment design clinical trial at 23 clinical centers comparing systemic corticosteroid therapy (and immunosuppression when indicated) with fluocinolone acetonide implant placement.

Methods

Eligible patients had active or recently active noninfectious intermediate uveitis, posterior uveitis, or panuveitis. The study design had 90% power (2-sided type I error rate, 0.05) to detect a 7.5-letter (1.5-line) difference between groups in the mean visual acuity change between baseline and 2 years. Secondary outcomes include ocular and systemic complications of therapy

SUBMITTER: Multicenter Uveitis Steroid Treatment Trial Research Group 

PROVIDER: S-EPMC2975449 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature