Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.

ABSTRACT:

Context

Echocardiographic measures of left ventricular (LV) structure and function are heritable phenotypes of cardiovascular disease.

Objective

To identify common genetic variants associated with cardiac structure and function by conducting a meta-analysis of genome-wide association data in 5 population-based cohort studies (stage 1) with replication (stage 2) in 2 other community-based samples.

Design, setting, and participants

Within each of 5 community-based cohorts comprising the EchoGen consortium (stage 1; n = 12 612 individuals of European ancestry; 55% women, aged 26-95 years; examinations between 1978-2008), we estimated the association between approximately 2.5 million single-nucleotide polymorphisms (SNPs; imputed to the HapMap CEU panel) and echocardiogra

SUBMITTER: Vasan RS 

PROVIDER: S-EPMC2975567 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature