Admixture mapping of end stage kidney disease genetic susceptibility using estimated mutual information ancestry informative markers.

ABSTRACT:

Background

The question of a genetic contribution to the higher prevalence and incidence of end stage kidney disease (ESKD) among African Americans (AA) remained unresolved, until recent findings using admixture mapping pointed to the association of a genomic locus on chromosome 22 with this disease phenotype. In the current study we utilize this example to demonstrate the utility of applying a multi-step admixture mapping approach.

Methods

A multi-step case only admixture mapping study, consisted of the following steps was designed: 1) Assembly of the sample dataset (ESKD AA); 2) Design of the estimated mutual information ancestry informative markers (n = 2016) screening panel 3); Genotyping the sample set whose size was determined by a power analysis (n = 576) appropriate

SUBMITTER: Shlush LI 

PROVIDER: S-EPMC2975638 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature