Iron-sparing response of Mycobacterium avium subsp. paratuberculosis is strain dependent.

ABSTRACT:

Background

Two genotypically and microbiologically distinct strains of Mycobacterium avium subsp. paratuberculosis (MAP) exist - S and C MAP strains that primarily infect sheep and cattle, respectively. Concentration of iron in the cultivation medium has been suggested as one contributing factor for the observed microbiologic differences. We recently demonstrated that S strains have defective iron storage systems, leading us to propose that these strains might experience iron toxicity when excess iron is provided in the medium. To test this hypothesis, we carried out transcriptional and proteomic profiling of these MAP strains under iron-replete or -deplete conditions.

Results

We first complemented M.smegmatisΔideR with IdeR of C MAP or that derived from S MAP and compared t

SUBMITTER: Janagama HK 

PROVIDER: S-EPMC2975660 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature