Reversibility of object recognition but not spatial memory impairment following binge-like alcohol exposure in rats.

ABSTRACT: Excessive alcohol use leads to neurodegeneration in several brain structures including the hippocampal dentate gyrus and the entorhinal cortex. Cognitive deficits that result are among the most insidious and debilitating consequences of alcoholism. The object exploration task (OET) provides a sensitive measurement of spatial memory impairment induced by hippocampal and cortical damage. In this study, we examine whether the observed neurotoxicity produced by a 4-day binge ethanol treatment results in long-term memory impairment by observing the time course of reactions to spatial change (object configuration) and non-spatial change (object recognition). Wistar rats were assessed for their abilities to detect spatial configuration in the OET at 1 week and 10 weeks following the ethanol treat

SUBMITTER: Cippitelli A 

PROVIDER: S-EPMC2975859 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature