Streptococcus pneumoniae isolates expressing a capsule with epitopes of both serotypes 6A and 6B.

ABSTRACT: Four Streptococcus pneumoniae isolates expressing both 6A and 6B capsular serotypes were detected by a multiplex immunoassay. The sequence of WciP, a GT2-family glycosyltransferase, indicates that point mutation has compromised linkage specificity, allowing two alternative oligosaccharides to be synthesized. This finding highlights that mutation as well as recombination can mediate serotype change.

SUBMITTER: Sheppard CL 

PROVIDER: S-EPMC2976087 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature