Characterisation of a new regulator of BDNF signalling, Sprouty3, involved in axonal morphogenesis in vivo.

ABSTRACT: During development, many organs, including the kidney, lung and mammary gland, need to branch in a regulated manner to be functional. Multicellular branching involves changes in cell shape, proliferation and migration. Axonal branching, however, is a unicellular process that is mediated by changes in cell shape alone and as such appears very different to multicellular branching. Sprouty (Spry) family members are well-characterised negative regulators of Receptor tyrosine kinase (RTK) signalling. Knockout of Spry1, 2 and 4 in mouse result in branching defects in different organs, indicating an important role of RTK signalling in controlling branching pattern. We report here that Spry3, a previously uncharacterised member of the Spry family plays a role in axonal branching. We found that spr

SUBMITTER: Panagiotaki N 

PROVIDER: S-EPMC2976284 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature