Reorganization of the growth pattern of Schizosaccharomyces pombe in invasive filament formation.

ABSTRACT: The organization and control of polarized growth through the cell cycle of Schizosaccharomyces pombe, a single-celled eukaryote, have been studied extensively. We have investigated the changes in these processes when S. pombe differentiates to form multicellular invasive mycelia and have found striking alterations to the behavior of some of the key regulatory proteins. Cells at the tips of invading filaments are considerably more elongated than cells growing singly and grow at one pole only. The filament tip follows a strict direction of growth through multiple cell cycles. A group of proteins involved in the growth process and actin regulation, comprising Spo20, Bgs4, activated Cdc42, and Crn1, are all concentrated at the growing tip, unlike their distribution at both ends of single cells

SUBMITTER: Dodgson J 

PROVIDER: S-EPMC2976291 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature