Chemical synthesis of deuterium-labeled and unlabeled very long chain polyunsaturated fatty acids.

ABSTRACT: First syntheses of a deuterium-labeled very long C34-containing polyunsaturated fatty acid, C34:5n5.d(2), and three other unlabeled very long chain C30-32-containing polyunsaturated fatty acids are reported here. These syntheses were achieved by coupling chemically modified C22- and C20-containing polyunsaturated fatty acids with carbanions derived from arylalkyl sulfones, followed by sodium amalgam-mediated desulfonylation.

SUBMITTER: Maharvi GM 

PROVIDER: S-EPMC2976573 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature