Protein kinase A binds and activates heat shock factor 1.

ABSTRACT:

Background

Many inducible transcription factors are regulated through batteries of posttranslational modifications that couple their activity to inducing stimuli. We have studied such regulation of Heat Shock Factor 1 (HSF1), a key protein in control of the heat shock response, and a participant in carcinogenisis, neurological health and aging. As the mechanisms involved in the intracellular regulation of HSF1 in good health and its dysregulation in disease are still incomplete we are investigating the role of posttranslational modifications in such regulation.

Methodology/principal findings

In a proteomic study of HSF1 binding partners, we have discovered its association with the pleiotropic protein kinase A (PKA). HSF1 binds avidly to the catalytic subunit of PKA, (PKAcα)

SUBMITTER: Murshid A 

PROVIDER: S-EPMC2976705 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature