Macaque proteome response to highly pathogenic avian influenza and 1918 reassortant influenza virus infections.

ABSTRACT: The host proteome response and molecular mechanisms that drive disease in vivo during infection by a human isolate of the highly pathogenic avian influenza virus (HPAI) and 1918 pandemic influenza virus remain poorly understood. This study presents a comprehensive characterization of the proteome response in cynomolgus macaque (Macaca fascicularis) lung tissue over 7 days of infection with HPAI (the most virulent), a reassortant virus containing 1918 hemagglutinin and neuraminidase surface proteins (intermediate virulence), or a human seasonal strain (least virulent). A high-sensitivity two-dimensional liquid chromatography-tandem mass spectroscopy strategy and functional network analysis were implemented to gain insight into response pathways activated in macaques during influenza virus i

SUBMITTER: Brown JN 

PROVIDER: S-EPMC2977874 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature