Nogo receptor deletion and multimodal exercise improve distinct aspects of recovery in cervical spinal cord injury.

ABSTRACT: We tested the ability of two plasticity-promoting approaches to enhance recovery in a mouse model of incomplete spinal cord injury (SCI). Genetically, we reduced myelin-mediated inhibition of neural plasticity through Nogo66-receptor (NgR) gene deletion. Behaviorally, we utilized a novel multimodal exercise training paradigm. Adult mice of wild-type or NgR-null genotype were subjected to partial lateral hemisection (LHx) at C3-C4 with the intent of producing anatomically and functionally mild deficits. Exercise training or control treatment proceeded for 14 weeks. Behavioral outcomes were assessed prior to tract tracing and histological analysis. Genotype and training exerted differing effects on performance; training improved performance on a test related to the training regimen (task-spe

SUBMITTER: Harel NY 

PROVIDER: S-EPMC2978056 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature