Identification and structural analysis of C-terminally truncated collapsin response mediator protein-2 in a murine model of prion diseases.

ABSTRACT:

Background

Prion diseases are fatal neurodegenerative disorders that accompany an accumulation of the disease-associated form(s) of prion protein (PrPSc) in the central nervous system. The neuropathological changes in the brain begin with focal deposits of PrPSc, followed by pathomorphological abnormalities of axon terminal degeneration, synaptic loss, atrophy of dendritic trees, and eventual neuronal cell death in the lesions. However, the underlying molecular basis for these neuropathogenic abnormalities is not fully understood.

Results

In a proteomic analysis of soluble proteins in the brains of mice challenged intracerebrally with scrapie prion (Obihiro I strain), we found that the amount of the full-length form of collapsin response mediator protein-2 (CRMP-2; 61 kDa) d

SUBMITTER: Shinkai-Ouchi F 

PROVIDER: S-EPMC2978134 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature