Dynamic functional modules in co-expressed protein interaction networks of dilated cardiomyopathy.

ABSTRACT:

Background

Molecular networks represent the backbone of molecular activity within cells and provide opportunities for understanding the mechanism of diseases. While protein-protein interaction data constitute static network maps, integration of condition-specific co-expression information provides clues to the dynamic features of these networks. Dilated cardiomyopathy is a leading cause of heart failure. Although previous studies have identified putative biomarkers or therapeutic targets for heart failure, the underlying molecular mechanism of dilated cardiomyopathy remains unclear.

Results

We developed a network-based comparative analysis approach that integrates protein-protein interactions with gene expression profiles and biological function annotations to reveal dynamic

SUBMITTER: Lin CC 

PROVIDER: S-EPMC2978157 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature