Genetic and epigenetic characteristics of human multiple hepatocellular carcinoma.

ABSTRACT:

Background

Multiple carcinogenesis is one of the major characteristics of human hepatocellular carcinoma (HCC). The history of multiple tumors, that is, whether they derive from a common precancerous or cancerous ancestor or individually from hepatocytes, is a major clinical issue. Multiple HCC is clinically classified as either intratumor metastasis (IM) or multicentric carcinogenesis (MC). Molecular markers that differentiate IM and MC are of interest to clinical practitioners because the clinical diagnoses of IM and MC often lead to different therapies.

Methods

We analyzed 30 multiple tumors from 15 patients for somatic mutations of cancer-related genes, chromosomal aberrations, and promoter methylation of tumor suppressor genes using techniques such as high-resolution me

SUBMITTER: Taniguchi K 

PROVIDER: S-EPMC2978203 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature