Distinctive classes of GABAergic interneurons provide layer-specific phasic inhibition in the anterior piriform cortex.

ABSTRACT: The primary olfactory (or piriform) cortex is a trilaminar paleocortex that is seen increasingly as an attractive model system for the study of cortical sensory processing. Recent findings highlight the importance of γ-amino butyric acid (GABA)-releasing interneurons for the function of the piriform cortex (PC), yet little is known about the different types of interneurons in the PC. Here, we provide the first detailed functional characterization of the major classes of GABAergic interneurons in the anterior piriform cortex (aPC) and show how these classes differentially engage in phasic synaptic inhibition. By measuring the electrical properties of interneurons and combining this with information about their morphology, laminar location, and expression of molecular markers, we have identi

SUBMITTER: Suzuki N 

PROVIDER: S-EPMC2978245 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature