Antibody responses to prostate-associated antigens in patients with prostatitis and prostate cancer.

ABSTRACT:

Background

An important focus of tumor immunotherapy has been the identification of appropriate antigenic targets. Serum-based screening approaches have led to the discovery of hundreds of tumor-associated antigens recognized by IgG. Our efforts to identify immunologically recognized proteins in prostate cancer have yielded a multitude of antigens; however, prioritizing these antigens as targets for evaluation in immunotherapies has been challenging. In this report, we set out to determine whether the evaluation of multiple antigenic targets would allow the identification of a subset of antigens that are common immunologic targets in patients with prostate cancer.

Methods

Using a phage immunoblot approach, we evaluated IgG responses in patients with prostate cancer (n = 126)

SUBMITTER: Maricque BB 

PROVIDER: S-EPMC2978272 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature