Whole genome sequencing highlights genetic changes associated with laboratory domestication of C. elegans.

ABSTRACT: Defining the mutational landscape when individuals of a species grow separately and diverge over many generations can provide insights into trait evolution. A specific example of this involves studying changes associated with domestication where different lines of the same wild stock have been cultivated independently in different standard environments. Whole genome sequence comparison of such lines permits estimation of mutation rates, inference of genes' ancestral states and ancestry of existing strains, and correction of sequencing errors in genome databases. Here we study domestication of the C. elegans Bristol strain as a model, and report the genome sequence of LSJ1 (Bristol), a sibling of the standard C. elegans reference wild type N2 (Bristol). The LSJ1 and N2 lines were cultivated

SUBMITTER: Weber KP 

PROVIDER: S-EPMC2978686 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature