Molecular characterization of the mouse superior lateral parabrachial nucleus through expression of the transcription factor Runx1.

ABSTRACT:

Background

The ability to precisely identify separate neuronal populations is essential to the understanding of the development and function of different brain structures. This necessity is particularly evident in regions such as the brainstem, where the anatomy is quite complex and little is known about the identity, origin, and function of a number of distinct nuclei due to the lack of specific cellular markers. In this regard, the gene encoding the transcription factor Runx1 has emerged as a specific marker of restricted neuronal populations in the murine central and peripheral nervous systems. The aim of this study was to precisely characterize the expression of Runx1 in the developing and postnatal mouse brainstem.

Methods and principal findings

Anatomical and immunohis

SUBMITTER: Zagami CJ 

PROVIDER: S-EPMC2978708 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature