Association of a polyadenylation polymorphism in the serotonin transporter and panic disorder.

ABSTRACT:

Background

Genetic markers in the serotonin transporter are associated with panic disorder (PD). The associated polymorphisms do not include the serotonin transporter-linked polymorphic region and display no obvious functional attributes. A common polymorphism (rs3813034) occurs in one of the two reported polyadenylation signals for the serotonin transporter and is in linkage disequilibrium with the PD-associated markers. If functional, rs3813034 might be the risk factor that explains the association of the serotonin transporter and PD.

Methods

Quantitative polymerase chain reaction on human brain samples (n = 65) and lymphoblast cultures (n = 71) was used to test rs3813034 for effects on expression of the polyadenylation forms of the serotonin transporter. rs3813034 was als

SUBMITTER: Gyawali S 

PROVIDER: S-EPMC2980348 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature