Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity.

ABSTRACT:

Background

Obesity is a strong risk factor for resistance to insulin-mediated glucose disposal, a precursor of type 2 diabetes and other disorders. However, not all obese individuals are insulin resistant. We sought to identify the molecular pathways that might cause obesity-associated insulin resistance in humans by studying the morbidly obese who were insulin sensitive versus insulin resistant, thereby eliminating obesity as a variable.

Methods

Combining gene expression profiling with computational approaches, we determined the global gene expression signatures of omental and subcutaneous adipose tissue samples obtained from similarly obese patients undergoing gastric bypass surgery.

Results

Gene sets related to chemokine activity and chemokine receptor binding were

SUBMITTER: Hardy OT 

PROVIDER: S-EPMC2980798 | biostudies-literature | 2011 Jan-Feb

REPOSITORIES: biostudies-literature