Effect of phylloquinone supplementation on glucose homeostasis in humans.

ABSTRACT:

Background

Under-γ-carboxylated osteocalcin (ucOC) increases insulin secretion and decreases glucose concentrations in mice.

Objective

We determined whether changes in ucOC concentrations in humans were associated with changes in insulin and glucose concentrations.

Design

Twenty-one community-dwelling postmenopausal women received 1 mg phylloquinone daily for 12 mo (experimental group), and 21 subjects were treated with a placebo during the same period (control group). Total serum osteocalcin, ucOC, glucose, and insulin concentrations were measured before and 6 and 12 mo after treatment. The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated and correlated with ucOC concentrations.

Results

Before administration of the placebo or phylloq

SUBMITTER: Kumar R 

PROVIDER: S-EPMC2980972 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature