Abnormal nocturnal heart rate variability response among chronic kidney disease and dialysis patients during wakefulness and sleep.

ABSTRACT:

Background

Dialysis patients and patients with chronic kidney disease (CKD) experience a substantial risk for abnormal autonomic function and abnormal heart rate variability (HRV). It remains unknown whether HRV changes across sleep stages in patients with different severity of CKD or dialysis dependency. We hypothesized that high-frequency (HF) HRV (vagal tone) will be attenuated from wakefulness to non-rapid eye movement (NREM) and then to rapid eye movement (REM) sleep in dialysis patients as compared to patients with CKD.

Methods

In-home polysomnography was performed in 95 patients with stages 4-5 CKD or end-stage renal disease (ESRD) on haemodialysis (HD) or peritoneal dialysis (PD). HRV was measured using fast Fourier transform of interbeat intervals during wakefulness

SUBMITTER: Roumelioti ME 

PROVIDER: S-EPMC2980993 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature