Characterization of a novel riboswitch-regulated lysine transporter in Aggregatibacter actinomycetemcomitans.

ABSTRACT: Aggregatibacter actinomycetemcomitans is an opportunistic pathogen that resides primarily in the mammalian oral cavity. In this environment, A. actinomycetemcomitans faces numerous host- and microbe-derived stresses, including intense competition for nutrients and exposure to the host immune system. While it is clear that A. actinomycetemcomitans responds to precise cues that allow it to adapt and proliferate in the presence of these stresses, little is currently known about the regulatory mechanisms that underlie these responses. Many bacteria use noncoding regulatory RNAs (ncRNAs) to rapidly alter gene expression in response to environmental stresses. Although no ncRNAs have been reported in A. actinomycetemcomitans, we propose that they are likely important for colonization and persiste

SUBMITTER: Jorth P 

PROVIDER: S-EPMC2981213 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature