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LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus.

ABSTRACT: A multidrug efflux pump designated LmrS (lincomycin resistance protein of Staphylococcus aureus), belonging to the major facilitator superfamily (MFS) of transporters, was cloned, and the role of LmrS in antimicrobial efflux was evaluated. The highest relative increase in MIC, 16-fold, was observed for linezolid and tetraphenylphosphonium chloride (TPCL), followed by an 8-fold increase for sodium dodecyl sulfate (SDS), trimethoprim, and chloramphenicol. LmrS has 14 predicted membrane-spanning domains and is homologous to putative lincomycin resistance proteins of Bacillus spp., Lactobacillus spp., and Listeria spp.

SUBMITTER: Floyd JL 

PROVIDER: S-EPMC2981259 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus.

Floyd Jody L JL   Smith Kenneth P KP   Kumar Sanath H SH   Floyd Jared T JT   Varela Manuel F MF  

Antimicrobial agents and chemotherapy 20100920 12

A multidrug efflux pump designated LmrS (lincomycin resistance protein of Staphylococcus aureus), belonging to the major facilitator superfamily (MFS) of transporters, was cloned, and the role of LmrS in antimicrobial efflux was evaluated. The highest relative increase in MIC, 16-fold, was observed for linezolid and tetraphenylphosphonium chloride (TPCL), followed by an 8-fold increase for sodium dodecyl sulfate (SDS), trimethoprim, and chloramphenicol. LmrS has 14 predicted membrane-spanning do  ...[more]

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