Enrichment map: a network-based method for gene-set enrichment visualization and interpretation.

ABSTRACT:

Background

Gene-set enrichment analysis is a useful technique to help functionally characterize large gene lists, such as the results of gene expression experiments. This technique finds functionally coherent gene-sets, such as pathways, that are statistically over-represented in a given gene list. Ideally, the number of resulting sets is smaller than the number of genes in the list, thus simplifying interpretation. However, the increasing number and redundancy of gene-sets used by many current enrichment analysis software works against this ideal.

Principal findings

To overcome gene-set redundancy and help in the interpretation of large gene lists, we developed "Enrichment Map", a network-based visualization method for gene-set enrichment results. Gene-sets are organized in

SUBMITTER: Merico D 

PROVIDER: S-EPMC2981572 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature