Hapalindole-related alkaloids from the cultured cyanobacterium Fischerella ambigua.

ABSTRACT: Four hapalindole-related alkaloids, namely fischambiguines A and B, ambiguine P, ambiguine Q nitrile as well as ambiguine G nitrile were identified from the cultured cyanobacterium Fischerella ambigua (UTEX 1903). The structures were determined by spectroscopic analysis including MS, 1D and 2D NMR and X-ray crystallography. The alkaloids possessed fused pentacyclic and hexacyclic carbon skeletons. Fischambiguine B displayed a strong inhibitory activity against Mycobacterium tuberculosis with an MIC value of 2 ?M, with no detectable cytotoxicity in a Vero cell line.

SUBMITTER: Mo S 

PROVIDER: S-EPMC2981615 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature