Subcellular metabolic organization in the context of dynamic energy budget and biochemical systems theories.

ABSTRACT: The dynamic modelling of metabolic networks aims to describe the temporal evolution of metabolite concentrations in cells. This area has attracted increasing attention in recent years owing to the availability of high-throughput data and the general development of systems biology as a promising approach to study living organisms. Biochemical Systems Theory (BST) provides an accurate formalism to describe biological dynamic phenomena. However, knowledge about the molecular organization level, used in these models, is not enough to explain phenomena such as the driving forces of these metabolic networks. Dynamic Energy Budget (DEB) theory captures the quantitative aspects of the organization of metabolism at the organism level in a way that is non-species-specific. This imposes constraints o

SUBMITTER: Vinga S 

PROVIDER: S-EPMC2981975 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature