Paradoxical instability-activity relationship defines a novel regulatory pathway for retinoblastoma proteins.

ABSTRACT: The retinoblastoma (RB) transcriptional corepressor and related family of pocket proteins play central roles in cell cycle control and development, and the regulatory networks governed by these factors are frequently inactivated during tumorigenesis. During normal growth, these proteins are subject to tight control through at least two mechanisms. First, during cell cycle progression, repressor potential is down-regulated by Cdk-dependent phosphorylation, resulting in repressor dissociation from E2F family transcription factors. Second, RB proteins are subject to proteasome-mediated destruction during development. To better understand the mechanism for RB family protein instability, we characterized Rbf1 turnover in Drosophila and the protein motifs required for its destabilization. We sho

SUBMITTER: Acharya P 

PROVIDER: S-EPMC2982090 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature