Type II transforming growth factor-beta receptor recycling is dependent upon the clathrin adaptor protein Dab2.

ABSTRACT: Transforming growth factor (TGF)-β family proteins form heteromeric complexes with transmembrane serine/threonine kinases referred to as type I and type II receptors. Ligand binding initiates a signaling cascade that generates a variety of cell type-specific phenotypes. Whereas numerous studies have investigated the regulatory activities controlling TGF-β signaling, there is relatively little information addressing the endocytic and trafficking itinerary of TGF-β receptor subunits. In the current study we have investigated the role of the clathrin-associated sorting protein Disabled-2 (Dab2) in TGF-β receptor endocytosis. Although small interfering RNA-mediated Dab2 knockdown had no affect on the internalization of various clathrin-dependent (i.e., TGF-β, low-density lipoprotein, or transf

SUBMITTER: Penheiter SG 

PROVIDER: S-EPMC2982134 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature