Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains.

ABSTRACT:

Background

Alzheimer's disease (AD) is a major neurodegenerative disorder leading to amnesia, cognitive impairment and dementia in the elderly. Usually this type of lesions results from dysfunctional protein cooperations in the biological pathways. In addition, AD progression is known to occur in different brain regions with particular features. Thus identification and analysis of crosstalk among dysregulated pathways as well as identification of their clusters in various diseased brain regions are expected to provide deep insights into the pathogenetic mechanism.

Results

Here we propose a network-based systems biology approach to detect the crosstalks among AD related pathways, as well as their dysfunctions in the six brain regions of AD patients. Through constructing a net

SUBMITTER: Liu ZP 

PROVIDER: S-EPMC2982685 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature