Discovering conditional co-regulated protein complexes by integrating diverse data sources.

ABSTRACT:

Background

Proteins interacting with each other as a complex play an important role in many molecular processes and functions. Directly detecting protein complexes is still costly, whereas many protein-protein interaction (PPI) maps for model organisms are available owing to the fast development of high-throughput PPI detecting techniques. These binary PPI data provides fundamental and abundant information for inferring new protein complexes. However, PPI data from different experiments do not overlap very much usually. The main reason is that the functions of proteins can activate only on certain environment or stimulus. In a short, PPI is condition-specific. Therefore specifying the conditions on when complexes are present is necessary for a deep understanding of their behaviours

SUBMITTER: Luo F 

PROVIDER: S-EPMC2982691 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature