Inhibition of the interactions between eosinophil cationic protein and airway epithelial cells by traditional Chinese herbs.

ABSTRACT:

Background

The eosinophil cationic protein (ECP) is cytotoxic to bacteria, viruses, parasites and mammalian cells. Cells are damaged via processes of pore formation, permeability alteration and membrane leaking. Some clinical studies indicate that ECP gathers in the bronchial tract of asthma sufferers, damages bronchial and airway epithelial cells, and leads to in breathing tract inflammation; therefore, prevention of the cytotoxicity caused by ECP may serve as an approach to treat airway inflammation. To achieve the purpose, reduction of the ECP-cell interactions is rational. In this work, the Chinese herbal combinative network was generated to predict and identify the functional herbs from the pools of prescriptions. It was useful to select the node herbs and to demonstrate the r

SUBMITTER: Chang HT 

PROVIDER: S-EPMC2982695 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature