Effects of anesthesia on the response to sleep deprivation.

ABSTRACT:

Study objective

Slow wave activity (SWA) during NREM sleep is the best characterized marker of sleep homeostasis, and the occurrence of sleep slow waves is necessary to reduce sleep need. Recent evidence suggests that sleep slow waves may mediate several beneficial effects of sleep on performance, from the prevention of cognitive impairments to memory consolidation. However, slow waves are also triggered by low doses of many anesthetics, but very few reports have examined whether anesthesia-mediated slow waves affect the homeostatic regulation of sleep. Moreover, no study has examined how sleep is affected by higher doses of anesthetics, which lead to a predominantly "isoelectric" EEG tracing without slow waves.

Design

We studied in rats whether 1 hour of a dose of isofluran

SUBMITTER: Nelson AB 

PROVIDER: S-EPMC2982736 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature