Ontology highlight
ABSTRACT:
SUBMITTER: Gu C
PROVIDER: S-EPMC2982766 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
The EMBO journal 20101008 21
The large GTPase dynamin assembles into higher order structures that are thought to promote endocytosis. Dynamin also regulates the actin cytoskeleton through an unknown, GTPase-dependent mechanism. Here, we identify a highly conserved site in dynamin that binds directly to actin filaments and aligns them into bundles. Point mutations in the actin-binding domain cause aberrant membrane ruffling and defective actin stress fibre formation in cells. Short actin filaments promote dynamin assembly in ...[more]